CRISPR-Cas9 Gene Editing Solutions

The CRISPR-Cas9 system is a revolutionary genome editing technology that enables targeted modifications in the DNA of living organisms with high precision and efficiency. By combining a Cas9 nuclease with a customizable guide RNA (gRNA), researchers can perform site-specific double-stranded breaks, enabling knockouts, insertions, and base editing in a wide range of species.

This catalog presents a curated selection of CRISPR-Cas9 all-in-one vector systems, target-specific gRNA sets, and validated recombinant Cas9 proteins—covering human, mouse, rat, and plant models.

CRISPR All-in-One Vectors

1. Contain both Cas9 nuclease and gRNA cassette in a single construct.
2. Available for Human, Mouse, and Rat targets.
3. Multiple promoters for cell-specific expression.

Examples:

1. RPL9P5 CRISPR All-in-One AAV Vector Set (Human)
2. RPS20 CRISPR All-in-One AAV Vector Set (Human)
3. RPS26 CRISPR All-in-One AAV Vector Set (Mouse)

Cas9 Recombinant Proteins

1. High-purity Cas9 nuclease for in vitro editing assays.
2. Available in NLS-tagged and nickase variants.
3. Ideal for RNP (ribonucleoprotein) delivery to cells.

Examples:

1. Recombinant Cas9 Protein – High-purity, nuclease-active.
2. Cas9 Nickase (D10A) – Single-strand break generation for HDR-based editing.

gRNA Libraries and Sets

1. Custom-designed or pre-validated sequences targeting specific genes.
2. Available as synthetic RNAs or vector-encoded gRNAs.
3. Suitable for pooled CRISPR screens and individual gene targeting.

Antibodies for CRISPR Components

1. Anti-Cas9 and Anti-gRNA-binding domain antibodies for verification.
2. Useful in Western blot, immunofluorescence, and ELISA.

1. Validated Performance – Every vector and gRNA is sequence-verified.
2. Species-Specific Optimization – Custom promoter and codon usage.
3. Flexible Formats – Plasmid, AAV, or RNP delivery systems.
4. Broad Coverage – From basic research to translational applications.

All products in this catalog are available for order via the provided links.

For custom CRISPR design, bulk supply, or technical consultation, please contact the Gentaur research support team.