Alpha-1-acid glycoprotein 1 is a protein that in humans is encoded by the ORM1 gene. This gene encodes a key acute phase plasma protein. Because of its increase due to acute inflammation, this protein is classified as an acute-phase reactant. The specific function of this protein has not yet been determined; however, it may be involved in aspects of immunosuppression. ORM1 has been shown to interact with Plasminogen activator inhibitor-1.