Regulates central hypertension through its calcium-modulated preference to cleave N-terminal acidic residues from peptides such as angiotensin II. ENPEP is considered to be an essential and highly specific enzyme, which metabolizes and inactivates bioactive peptides such as angiotensin II (AngII) in the renin-angiotensin system. ENPEP is expressed in neoplastic lesions of the uterine cervix, and its levels are upregulated as the lesions progress from cervical intraepithelial neoplasms to invasive squamous cell carcinomas. ENPEP expression is absent in normal cells and is overexpressed in cancer cell lines compared with normal cells of mammary origin.