Caspase-6 is an enzyme that in humans is encoded by the CASP6 gene.CASP6 orthologs have been identified in numerous mammals for which complete genome data are available. Unique orthologs are also present in birds, lizards, lissamphibians, and teleosts. Caspase-6 has known functions in apoptosis,early immune response and neurodegeneration in Huntington's and Alzheimer's disease.