Receptor for C-C type chemokine. Binds and responds to a variety of chemokines, including CCL11, CCL26, CCL7, CCL13, RANTES (CCL5) and CCL15 . Subsequently transduces a signal by increasing the intracellular calcium ions level . In addition acts as a possible functional receptor for NARS1 . (Microbial infection) Alternative coreceptor with CD4 for HIV-1 infection. Overexpression of CCR3 together with its ligands appears to be a characteristic of ulcerative colitis (UC). The production of CCR3 ligands by human colonic epithelial cells suggests further that the epithelium can play a role in modulating pathological T-cell-mediated mucosal inflammation.