HypoGel® is a hydrophilic Gel® type resin which combines high capacities with good solvent compatibility. Glycol spacers with n = 5 or 10 EO units separate the reactive sites from the polystyrene matrix and modify the hydrophobic properties of the polystyrene backbone. Due to the spacer effect the functional group shows a higher mobility which results in higher kinetic rates and high resolution NMR spectra from immobilized compounds on the bead. The resin is compatible to a wide range of solvents and in contrast to polystyrene even polar solvents like methanol or ethanol can be used. These resins show high loading and a hydrophilicity between polystyrene and TentaGel®. This aldehyde resin is synthesized from HypoGel® amine acylated with 6-oxo-caproic acid. The resin is useful for the reversible protection of primary amine substrates via formation of a Schiff's base. In this resin the glycol spacer contains 10 EO units which separate the reactive sites from the polystyrene matrix.