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  3. LRP6 Mouse Monoclonal Antibody [A5E7]
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LRP6 Mouse Monoclonal Antibody [A5E7]

Product ID: 8228218


Gentaur Catalog Number

GTR09933645
Select size

100 µL

$695.11
​
Selected
100 µL

$695.11

1

Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation.