Neuregulin 3 also known as NRG3 is a neural-enriched member of the neuregulin protein family which in humans is encoded by the NRG3 gene.[5][6] The NRGs are a group of signaling proteins part of the superfamily of epidermal growth factor; EGF like polypeptide growth factor. These groups of proteins possess an 'EGF-like domain' that consists of six cysteine residues and three disulfide bridges predicted by the consensus sequence of the cysteine residues. Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. Does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. May be a survival factor for oligodendrocytes.