SensiStain™ Anti-PAX-8 Antibody is in ready-to-use format. PAX-8 belongs to the paired box (PAX) family of transcription factors which play an important role in early development such as with thyroid follicular cells and the expression of thyroid-specific genes; however mutations in the PAX8 gene is found to be associated with thyroid follicular carcinomas. PAX-8 is also found to be expressed in simple ovarian inclusion cysts and non-ciliated mucosal cells of the fallopian tubes. It has been found to be as useful marker for renal epithelial tumors, ovarian cancer and for differential diagnoses in lung and neck tumors. Anti-PAX-8 can be used in conjunction with other markers such as uroplakin, mammaglobin and TTF-1 to determine the primary sites of invasive micropapilary carcinomas of ovary.