Transmembrane protein 248 is a protein that is encoded by the TMEM248 gene. TMEM248, also known as C7orf42, is a gene that is found in humans and encodes a transmembrane protein with a function that is not yet well understood by the scientific community. This gene contains four transmembrane domains, and is composed of six exons. The protein TMEM248 encodes is 314 amino acid long protein containing four transmembrane regions. The theoretical molecular weight of the 314 amino acid TMEM248 protein is approximately 35kDa and the theoretical pI is approximately 6. TMEM248 is expected to have a subcellular localization in the plasma membrane and vesicles. Based on predictions from Chou and Fasman Secondary Structure Prediction Server, TMEM248 is primarily made up of beta sheets and helices. TMEM248 protein has four transmembrane domains. TMEM248 (transmembrane protein 248), or C7orf42 (chromosome 7, open reading frame 42) is predicted to be an integral component of the plasma membrane. It has low tissue specificity, meaning it is expressed in most tissues throughout the human body. TMEM248 has cytoplasmic expression in multiple different tissue types, but is the most abundant in the gastrointestinal tract. TMEM248 may play a role in cancer development. It was shown to be more highly expressed in cases of colon, breast, lung, ovarian, brain, and renal cancers.